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Innovative Platform for Discovery and Development of Biopharmaceuticals, Peptides, and Wide Range of Proteins
The iCapTag™ Technology
The iCapTag™ Technology can be used in R&D Labs and Manufacturing Facilities
The iCapTag™ technology is the first product on the market today that can be used to purify tagless non-mAb proteins for both R&D and manufacturing. Inteins are protein segments with the ability to excise themselves from the host proteins through the process of protein splicing. Engineered self-cleaving inteins can used for recombinant protein purification and for other applications.
An additional benefit of this technology is that a simple single-column purification can result in high purity of the target protein, where the release of the target protein from the column is triggered by a change in pH.
Protein Purification Steps Using the iCapTag™ Technology
Examples of Protein Purification
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Acknowledgements
Protein Capture Science team would like to thank federal governmental agencies and private companies for supporting development of this innovative technology and many previous prototype iterations, which cumulatively led to iCapTag platform development. Many thanks go to wonderful teams supporting commercialization of iCapTag technology during the COVID-19 pandemic and grant agencies, including State of Ohio, Ohio Third Frontier, Ohio Development Services Agency, Rev1 Ventures, the Ohio State University, extraordinary collaborators and vendors.
